Kwame Nsiah-Apau (born 17th April 1976), known by his stage name Okyeame Kwame and nicknamed Rap Doctor, is a Ghanaian musician, songwriter, creative director and entrepreneur.

Apau was born in Kumasi, Ashanti Region of Ghana. He is the third of six siblings. His two younger brothers, Kwaku Nsiah Boamah nicknamed "Flowking Stone" and Kwaku Nsiah Amankwah nicknamed "Kunta Kinte", also perform as a duo, under the brand name "Bradez". Growing up, Kwame's parents expected him to become a physician, yet he gained interest in rap music from a very young age, when he wrote his own songs and performed at local shows since his days at the Anglican Senior High School in Kumasi.

In 1997, he achieved notoriety as a member of the "Akyeame" hiplife duo, together with fellow Ghanaian Daniel Kofi Amoateng (under the stage name Okyeame Kofi). They recorded together the albums, "Nyansapo" ("Witty Knot", 1997), "Nkonsonkonson" ("Shackles", 1998), "Ntoaso" ("Continuity", 2000) and "Apam Foforo" ("New Testament", 2002). He performed a solo under his own record label "One Mic Entertainment", in Accra since they parted in 2004.[10][11] He also featured some renowned Ghanaian highlife and hiplife artists like Daddy Lumba, Kojo Antwi and Ofori Amponsah.

For declaring himself B.R.A (Best Rapper Alive) in a song he recorded after winning Ghana Music Awards Artist of the Year award in 2009, Okyeame Kwame sparked a conflict with fellow Ghanaian rapper Obrafour, who saw himself more deserving. This resulted in one of the most memorable feuds the Ghanaian music scene has seen, with Obrafour challenging Okyeame Kwame to a rap battle on the streets which was never honored. In 2011, after Obrafour had apologized for his actions, Okyeame Kwame explained he declined Obrafour's challenge because there was no need for it at the time, as winning Artist of the Year was vindictive enough.

Okyeame Kwame has made significant contributions to education and scholarship promotion, his rap lyrics (which incorporate didactic themes, social consciousness and poetry) are being studied in some Ghanaian universities. He recently came out with a song titled "Yeeko" ft Ghana's very own highlife artist Kuami Eugene.